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3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)

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3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+)
Identifiers
EC no.1.1.1.239
CAS no.126469-82-7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
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MetaCycmetabolic pathway
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In enzymology, a 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) (EC 1.1.1.239) is an enzyme that catalyzes the chemical reaction:

testosterone + NAD+ androst-4-ene-3,17-dione + NADH + H+

Thus, the two substrates of this enzyme are testosterone and NAD+, whereas its 3 products are androst-4-ene-3,17-dione, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3alpha(or 17beta)-hydroxysteroid:NAD+ oxidoreductase. Other names in common use include 3alpha,17beta-hydroxy steroid dehydrogenase, 3alpha(17beta)-HSD, and 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+). This enzyme participates in androgen and estrogen metabolism.

See also

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References

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  • Ohmura M, Hara A, Nakagawa M, Sawada H (1990). "Demonstration of 3α(17β)-hydroxysteroid dehydrogenase distinct from 3α-hydroxysteroid dehydrogenase in hamster liver". Biochem. J. 266 (2): 583–9. PMC 1131171. PMID 2317205.